Buttle's World

20 July, 2009

Evolutionary Insight

Filed under: Posts — clgood @ 22:07

A potential mechanism has been found for what seem to be “leaps” in evolution. For example, there is no middle ground on the number of wings on an insect or limbs on a primate. So how is the “jump” made? It could be “partial penetrance.”

“If you take a bunch of cells and grow them in exactly the same environment, they’ll be identical twin brothers in terms of the genes they have, but they may still show substantial differences in their behavior,” says Avigdor Eldar, a postdoctoral scholar in biology at Caltech and the paper’s first author. These sorts of variations—or noise, as the researchers call it—can actually allow a mutation to have an effect in some organisms but not in others. For example, while some genetically variable cells will show the expected effect of the mutation, others may still behave like a normal, or wild type, cell. And still others may do something else entirely.
“These mutant cells don’t only show a different morphology,” Eldar notes. “They show more variability in their behavior. In a population, you can see a mixture of several different behaviors, with some cells doing one thing and others doing something else.”

Remembering Shifty

Filed under: Posts — clgood @ 14:44

I’ve already ReTweeted this.

When Powers died, to little fanfare in June, a man named Mark Pfeifer (retired from Dow Jones) was appalled by the disproportionate amount of coverage given to Michael Jackson. He penned an e-mail about a chance encounter he had had with the humble war hero at the Philadelphia airport. The e-mail went viral as friends forwarded to friends.

Take a moment to remember Shifty Powers today.

Great footage of that One Small Step

Filed under: Posts — clgood @ 8:24

Here, thanks to Bad Astronomy is some great footage of Neil Armstrong taking that giant leap for mankind.

Update:

You can read the entire mission transcript. A coworker found a nice exchange on page 295:

CAPCOM         Roger. Among the large headlines concerning Apollo this morning there’s one asking that you watch for a lovely girl with a big rabbit. An ancient legend says a beautiful Chinese girl called Chango has been living there for 4,000 years. It seems she was banished to the moon because she stole the pill for immortality from her husband. You might also look for her companion, a large Chinese rabbit, who is easy to spot since he is only standing on his hind feet in the shade of a cinnamon tree. The name of the rabbit is not recorded.

SC         Okay, we’ll keep a close eye for the bunny girl.

Iran’s “Suspended” Nuke Program

Filed under: Posts — clgood @ 8:09

I’m shocked – shocked – to learn that the 2007 NIE claim that Iran suspended its nuclear program in 2003 has been contradicted.

The Bundesnachrichtendienst (BND), Germany’s foreign intelligence agency, has amassed evidence of a sophisticated Iranian nuclear weapons program that continued beyond 2003. This usually classified information comes courtesy of Germany’s highest state-security court. In a 30-page legal opinion on March 26 and a May 27 press release in a case about possible illegal trading with Iran, a special national security panel of the Federal Supreme Court in Karlsruhe cites from a May 2008 BND report, saying the agency “showed comprehensively” that “development work on nuclear weapons can be observed in Iran even after 2003.”

Unlikely Savior

Filed under: Posts — clgood @ 6:32

Last night I happened to catch part of a History Detectives episode on PBS. It had to do with premature babies being exhibited as part of a sideshow at the 1933 and 1934 Chicago World’s Fair. (PDF transcript here)

At first, of course, the thought of a German doctor putting infants on display between Sally Rand and the freak show seems apalling. How stereotypical, I thought: A German. Fortunately they dug a bit deeper.

Until the middle part of the last century preemies had a very poor life expectancy. Most died in spite of efforts to keep them warm with blankets, hay, or being placed in shoe boxes next to stoves. Dr. Couney knew in the late 19th century that the new technology of incubators could save their lives.

But not only was the technology prohibitively expensive, most parents had their babies at home and didn’t trust them to doctors and nurses. So Couney faced a double challenge: To evangelize the technology and make it affordable. His solution was a brilliant example of how the free market saves lives.

Dr. William Silverman’s “Incubator-Baby Side Shows” Pediatrics 1979; 64:127-141. Dr. Silverman recounts the fascinating history of premature babies in incubators who were exhibited at World’s Fairs beginning in the late 19th century. An aspiring young actor named Archibald Leach worked as a barker outside one of these exhibits (“Don’t pass the babies by!”). He later acheived fame under his stage name — Cary Grant.

At the Chicago World’s Fair in 1933-4, the premature baby exhibit was next to the midway where Sally Rand and her fan dancers were performing. When police raided Sally Rand’s show she protested that her girls were wearing much more in the way of clothes than those babies next door. The article has *wonderful* pictures of very tiny preemies with their parents, nurses, doctors; it also shows old incubators, and various caregiving techniques including a very scary picture of “nasal spoon feeding.”

Another interesting article is by Dr. Jeffrey Baker “The Incubator Controversy: Pediatricians and the Origins of Premature Infant Technology in the United States, 1890 to 1910” Pediatrics 1991;87:654-662. Dr. Baker explains why many physicians and parents at first rejected the use of incubators (developed in France) because they considered them to be unhygienic and because most parents (who gave birth at home) were reluctant to entrust their babies to doctors for hospital care.

However, I have an article from the San Francisco Chronicle of 1902 entitled “What Becomes of the Incubator Babies?” that is far more upbeat about the use of incubators. It begins: “Nine years ago one of the curiosities of the World’s Fair at Chicago was a baby incubator in full operation, taking care of a prematurely born baby, one of those helpless little changelings brought into the world alive and breathing, yet before its time. It was exhibited as a curiousity, a thing of wonder. Today, to raise a prematurely born baby without the assistance of an incubator would be like dressing a wound without antiseptic precaution.

While many in the press lambasted Couney’s exhibits, parents and doctors backed him up. Not surprising, when you consider that he saved the lives of hundreds of their children with a technology they could not afford.

Once hospitals caught on, Couney stopped the exhibits. How’s that German Doctor stereotype holding up now?

Kurt Cobain (Rick) Rolling in His Grave

Filed under: Posts — clgood @ 6:04

H/T: Mashable.

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